With the young manager now swapping dugout it remains to be seen how competitive Leipzig will be and bet365 price a home win at 21/10 (3.10).
Bayern, meanwhile, can be backed at 23/20 (2.15) with the draw at 14/5 (3.80).
TV channel, live stream & how to watch
UK TV channel
Sky Sports Football Sky Go
The game is being shown live on Sky Sports Football in the United Kingdom (UK). Sky Go will be streaming the game live online.
RB Leipzig vs Bayern Munich team news
The hosts remain without injured full-back Angelino, while summer signing from Barcelona – Ilaix Moriba – could get his first minutes with his new club.
Bayern remain without Benjamin Pavard and Kingsley Coman who are both injured, but otherwise have a full squad to choose from.
RB Leipzig vs Bayern Munich preview
While their away form last season was patchy, Leipzig remain a strong prospect at home where they have lost just one Bundesliga game since January.
That defeat did come against Bayern in April, although it was a tight game decided by a solitary Leon Goretzka strike.
The hosts boast a strong scoring record in front of their own fans and will feel they can get on the score sheet once more this weekend against a Bayern side that have conceded goals already this term.
Borussia Dortmund, Borussia Monchengladbach and Koln have all scored in competitive games against Bayern so far this season and backing Leipzig to do so as well makes plenty of sense this weekend.
RB Leipzig vs Bayern Munich tips & predictions
Both teams to score is offered at just 2/5 (1.40) but both teams to score in the first half looks like an appealing option at 12/5 (3.40) with this selection paying out in two of the last four meetings.
Odds correct at the time of writing. Please gamble responsibly.